Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

Preclinical mouse models suggest that the gut microbiome modulates tumor response to
checkpoint blockade immunotherapy; however, this has not been well-characterized in …

Human gut microbiome composition is shaped by multiple factors but the relative
contribution of host genetics remains elusive. Here we examine genotype and microbiome …

Background Cancer is a heterogeneous disease with many genetic variations. Lines of
evidence have shown copy number variations (CNVs) of certain genes are involved in …

There is increasing evidence in humans and laboratory animals for biologically based sex
differences in every phase of drug addiction: acute reinforcing effects, transition from …

Genetic polymorphism varies among species and within genomes, and has important
implications for the evolution and conservation of species. The determinants of this variation …

A new data-driven computational framework is developed to assist in the design and
modeling of new material systems and structures. The proposed framework integrates three …

Abstract Background The Mediterranean mussel Mytilus galloprovincialis is an ecologically
and economically relevant edible marine bivalve, highly invasive and resilient to biotic and …