The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …

The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors
together with the discovery of their endogenous ligands in the late 80s and early 90s …

The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology
across human tissues in response to extracellular signals. GPCR-mediated signalling can …

An agonist that acts through a single receptor can activate numerous signaling pathways.
Recent studies have suggested that different ligands can differentially activate these …

CB1 receptors are G-protein coupled receptors (GPCRs) abundant in neurons, in which they
modulate neurotransmission. The CB1 receptor influence on memory and learning is well …

▪ Abstract The multitude of chemically highly different agonists for 7TM receptors apparently
do not share a common binding mode or active site but nevertheless act through induction of …

Multiple sclerosis is the most common inflammatory demyelinating disease of the central
nervous system, caused by an autoimmune response against myelin that eventually leads to …

BACKGROUND:: Cannabinoid receptors mediate the psychopharmacological action of
marijuana and have been localized in the central and peripheral nervous system as well as …

Three members of the ghrelin receptor family were characterized in parallel: the ghrelin
receptor, the neurotensin receptor 2 and the orphan receptor GPR39. In transiently …