The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Astrocytes are housekeepers of the central nervous system (CNS) and are important for
CNS development, homeostasis and defence. They communicate with neurones and other …

The intracellular calcium concentration ([Ca 2+]) has important roles in the triggering of
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …

Glucose-induced insulin secretion in response to a step increase in blood glucose
concentrations follows a biphasic time course consisting of a rapid and transient first phase …

Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following
pathological stress and are the underlying cause of several disease conditions. In …

In vitro studies suggest that the G protein-coupled receptor (GPR) 30 is a functional estrogen
receptor. However, the physiological role of GPR30 in vivo is unknown, and it remains to be …

Glucose‐stimulated biphasic insulin secretion involves at least two signaling pathways, the
Katp channel‐dependent and Katp channel‐independent pathways, respectively. In the …

The glucoregulatory hormones insulin and glucagon are released from the β-and α-cells of
the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials …

Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …