Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Mammalian cells depend on glucose as a major substrate for energy production. Glucose is
transported into the cell via facilitative glucose transporters (GLUT) present in all cell types …

Glucose is cleared from the bloodstream by a family of facilitative transporters (GLUTS),
which catalyze the transport of glucose down its concentration gradient and into cells of …

Many receptors for neurotransmitters and hormones rely upon members of the Gqα family of
heterotrimeric G proteins to exert their actions on target cells. Gα subunits of the Gq class of …

Type 2 diabetes (T2D) mellitus has emerged as a major global health concern that has
accelerated in recent years due to poor diet and lifestyle. Afflicted individuals have high …

Reactive oxygen species (ROS) have been implicated in many intra-and intercellular
processes. High levels of ROS are generated as part of the innate immunity in the …

Glucose serves as the major energy substrate and the main precursor for the synthesis of
glycosaminoglycans in chondrocytes. Facilitated glucose transport represents the first rate …

In skeletal muscle and adipose tissue, insulin-stimulated glucose uptake is dependent upon
translocation of the insulin-responsive glucose transporter GLUT4 from intracellular storage …

Uveal melanoma (UM) is the most common intraocular malignancy in adults. So far, no
systemic therapy or standard treatment exists to reduce the risk of metastasis and improve …

G protein-coupled receptors (GPCRs) play a major role in signal transduction and are
targets of many therapeutic drugs. The regulator of G protein signaling (RGS) proteins form a …