[HTML][HTML] PTH and vitamin D

SJ Khundmiri, RD Murray, E Lederer - Comprehensive Physiology, 2016 - ncbi.nlm.nih.gov
PTH and Vitamin D are two major regulators of mineral metabolism. They play critical roles
in the maintenance of calcium and phosphate homeostasis as well as the development and …

Ion channels and channelopathies in glomeruli

A Staruschenko, R Ma, O Palygin… - Physiological …, 2023 - journals.physiology.org
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease

L Zhou, Y Liu - Nature Reviews Nephrology, 2015 - nature.com
Podocytes are unique, highly specialized, terminally differentiated cells that are integral
components of the kidney glomerular filtration barrier. Podocytes are vulnerable to a variety …

TRPC channels in proteinuric kidney diseases

G Hall, L Wang, RF Spurney - Cells, 2019 - mdpi.com
Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential
cation channel, subfamily C, member 6) were linked to development of familial forms of …

Nuclear receptors in podocyte biology and glomerular disease

S Agrawal, JC He, PL Tharaux - Nature Reviews Nephrology, 2021 - nature.com
Nuclear receptors have a broad spectrum of biological functions in normal physiology and in
the pathology of various diseases, including glomerular disease. The primary therapies for …

[HTML][HTML] TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease

SE Dryer, H Roshanravan, EY Kim - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
Mutations in the gene encoding canonical transient receptor potential-6 (TRPC6) channels
result in severe nephrotic syndromes that typically lead to end-stage renal disease. Many …

Vitamin D and glomerulonephritis

G Gembillo, R Siligato, M Amatruda, G Conti, D Santoro - Medicina, 2021 - mdpi.com
Vitamin D presents a plethora of different functions that go beyond its role in skeletal
homeostasis. It is an efficient endocrine regulator of the Renin–Angiotensin–Aldosterone …

The calcium-dependent protease calpain-1 links TRPC6 activity to podocyte injury

KAT Verheijden, R Sonneveld… - Journal of the …, 2018 - journals.lww.com
Background The hallmark of podocytopathies, such as FSGS, is podocyte injury resulting in
proteinuria. Transient receptor potential channel C6 (TRPC6) is a calcium-conducting ion …

[HTML][HTML] Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner

R Sonneveld, J van der Vlag, MPA Baltissen… - The American journal of …, 2014 - Elsevier
Slit diaphragm and podocyte damage is crucial in the pathogenesis of proteinuria in diabetic
nephropathy (DNP). Gain-of-function mutations in TRPC6, a slit diaphragm–associated ion …

Sildenafil Prevents Podocyte Injury via PPAR-γ–Mediated TRPC6 Inhibition

R Sonneveld, JG Hoenderop, AM Isidori… - Journal of the …, 2017 - journals.lww.com
Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased
TRPC6 expression in podocytes induce glomerular injury and proteinuria. Sildenafil reduces …