The emerging role of the piRNA/piwi complex in cancer
Y Liu, M Dou, X Song, Y Dong, S Liu, H Liu, J Tao, W Li… - Molecular cancer, 2019 - Springer
Piwi interacting RNAs (piRNAs) constitute novel small non-coding RNA molecules of
approximately 24–31 nucleotides in length that often bind to members of the piwi protein …
approximately 24–31 nucleotides in length that often bind to members of the piwi protein …
PIWI proteins and PIWI-interacting RNAs in the soma
RJ Ross, MM Weiner, H Lin - Nature, 2014 - nature.com
The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unanticipated
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …
piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma
H Yan, QL Wu, CY Sun, LS Ai, J Deng, L Zhang… - Leukemia, 2015 - nature.com
Aberrant DNA hypermethylation contributes to myelomagenesis by silencing tumor-
suppressor genes. Recently, a few reports have suggested that a novel class of small non …
suppressor genes. Recently, a few reports have suggested that a novel class of small non …
The expression of stem cell protein Piwil2 and piR-932 in breast cancer
H Zhang, Y Ren, H Xu, D Pang, C Duan, C Liu - Surgical oncology, 2013 - Elsevier
Background To investigate the expression status of PIWIL2 and piR-932 in breast cancer
stem cells and the role they could play in tumor cell growth and metastasis through Latexin …
stem cells and the role they could play in tumor cell growth and metastasis through Latexin …
An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes
PIWI-interacting RNA (piRNA) silences the transposons in germlines or induces epigenetic
modifications in the invertebrates. However, its function in the mammalian somatic cells …
modifications in the invertebrates. However, its function in the mammalian somatic cells …
PIWI expression and function in cancer
R Suzuki, S Honda, Y Kirino - Frontiers in genetics, 2012 - frontiersin.org
PIWI proteins, a subclade of the Argonaute family proteins, are expressed predominantly in
the germline and bind to PIWI-interacting RNAs (piRNAs), which are 25–31 nucleotides in …
the germline and bind to PIWI-interacting RNAs (piRNAs), which are 25–31 nucleotides in …
[HTML][HTML] Piwil1 regulates glioma stem cell maintenance and glioblastoma progression
Piwi proteins are a subfamily of Argonaute proteins that maintain germ cells in eukaryotes.
However, the role of their human homologs in cancer stem cells, and more broadly in …
However, the role of their human homologs in cancer stem cells, and more broadly in …
NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma
Chromatin modifying enzymes are frequently mutated in cancer, resulting in widespread
epigenetic deregulation. Recent reports indicate that inactivating mutations in the histone …
epigenetic deregulation. Recent reports indicate that inactivating mutations in the histone …
Untangling the web: the diverse functions of the PIWI/piRNA pathway
SR Mani, CE Juliano - Molecular reproduction and …, 2013 - Wiley Online Library
Small RNAs impact several cellular processes through gene regulation. Argonaute proteins
bind small RNAs to form effector complexes that control transcriptional and post …
bind small RNAs to form effector complexes that control transcriptional and post …
MicroRNA-191, an estrogen-responsive microRNA, functions as an oncogenic regulator in human breast cancer
Estrogen-and microRNA-mediated gene regulation play a crucial role in breast cancer
biology. However, a functional link between the two major players remains unclear. This …
biology. However, a functional link between the two major players remains unclear. This …