In human cells, the integrity of genetic information is constantly challenged by endogenous
and exogenous chemical agents that can induce DNA damage. To counteract the …

The development of colorectal cancer (CRC) is a multistep process initiated by a benign
polyp that has the potential to evolve into in situ carcinoma through the interactions between …

Exposure to chemical pollution can induce genetic and epigenetic alterations,
developmental changes, and reproductive disorders, leading to population declines in …

The measurement of DNA adducts, the covalent modifications of DNA upon the exposure to
the environmental and dietary genotoxicants and endogenously produced electrophiles …

Although interest in characterizing DNA damage by means of DNA adductomics has
substantially grown, the field of DNA adductomics is still in its infancy, with room for …

Analytical chemistry has considerably benefited from the developments in the field of mass
spectrometry. The high resolution, mass accuracy, and sensitivity offered by modern mass …

DNA adducts can be induced by both endogenous and external sources. Qualitative and
quantitative characterizations of DNA adducts are crucial to understanding their roles in the …

Diesel engine exhaust (DEE), which is the product of diesel combustion, is considered
carcinogenic in humans. It comprises toxic gases, polycyclic aromatic hydrocarbons (PAHs) …

The consumption of red meat has been linked to an increased colorectal cancer (CRC) risk.
One of the major hypotheses states that heme iron (present in red meat) stimulates the …

About 20 years ago, the research group of Sheila Anne Bingham in Cambridge, UK, showed
for the first time that volunteers consuming large amounts of red meat excrete high amounts …