CD28 co-stimulation: Novel insights and applications in cancer immunotherapy
MT Lotze, SH Olejniczak, D Skokos - Nature Reviews Immunology, 2024 - nature.com
Substantial progress in understanding T cell signalling, particularly with respect to T cell co-
receptors such as the co-stimulatory receptor CD28, has been made in recent years. This …
receptors such as the co-stimulatory receptor CD28, has been made in recent years. This …
Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets
Z Hong, F Liu, Z Zhang - Experimental Hematology & Oncology, 2024 - Springer
Although immune checkpoint-based cancer immunotherapy has shown significant efficacy
in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is …
in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is …
Degron-based bioPROTACs for controlling signaling in CAR T cells
Chimeric antigen receptor (CAR) T cells have made a tremendous impact in the clinic, but
potent signaling through the CAR can be detrimental to treatment safety and efficacy. The …
potent signaling through the CAR can be detrimental to treatment safety and efficacy. The …
Co‐Expression of Dominant‐Negative TGF‐β Receptor 2 Enhances the Therapeutic Efficacy of Novel TREM1/DAP12‐BB‐Based CAR‐T Cells in Solid Tumours
S Zhu, J Hu, J Lin, C Wang, E Wang - Immunology, 2025 - Wiley Online Library
Chimeric antigen receptor (CAR) T‐cell therapy has exhibited remarkable efficacy in the
treatment of haematological malignancies, yet its application in solid tumours is hindered by …
treatment of haematological malignancies, yet its application in solid tumours is hindered by …
[HTML][HTML] Engineered Cellular Therapies for the Treatment of Thoracic Cancers
SM Erickson, BM Manning, A Kumar, MR Patel - Cancers, 2024 - mdpi.com
Thoracic malignancies (lung cancers and malignant pleural mesothelioma) are prevalent
worldwide and are associated with high morbidity and mortality. Effective treatments are …
worldwide and are associated with high morbidity and mortality. Effective treatments are …
Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy
In this issue of Cell Chemical Biology, Lane et al. 1 introduce a transgene-based system to
express fusion proteins that recruit transcription factors to E3 ligases. This approach …
express fusion proteins that recruit transcription factors to E3 ligases. This approach …