The ever increasing cases of microbial resistance pose a major threat to the scientific
community and therefore the need for discovery and development of newer antimicrobial …

Due to the unusual structure and chemical composition of the mycobacterial cell wall,
effective tuberculosis (TB) treatment is difficult, making many antibiotics ineffective and …

A series of imidazole based compounds were synthesized by reacting simple imidazoles
with alkyl halides or alkyl halocarboxylate in presence of tetrabutylammonium bromide …

The triazole analogs were obtained via. multistep synthesis sequence beginning with ethyl
nicotinoate 3 which on treatment with hydrazine hydrate yields nicotinoyl hydrazide 4 …

Objectives: To synthesize new antimycobacterial and antifungal drugs that act by binding to
sterol 14α-demethylase (14DM) and to characterize the drug–target protein interactions …

Abstract N1-[1-Aryl-2-(1H-imidazol-1-yl and 1H-1, 2, 4-triazol-1-yl)-ethylidene]-pyridine-2-
carbo xamidrazone derivatives were synthesized and tested for their in vitro antifungal and …

The less polar fraction of the methanolic extract from the plant Euphorbia peplis L. exhibited
interesting antifungal and antitubercular activity. A complex mixture of four …

A series of novel dihydropyrimidine derivatives bearing an imidazole nucleus at C-4 position
were synthesized in excellent yields via Biginelli multi-component reaction. The newly …

Khat is the name generally used for (Catha edulis Forsk), a young leaves and shoots of a
flowering evergreen tree or shrub that grows at high altitudes in the region extending from …

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb); it is
the world's one of common cause of death (Ducati et al., 2006). Aproxymate 2 million people …