Chromatin accessibility: methods, mechanisms, and biological insights
AR Mansisidor, VI Risca - Nucleus, 2022 - Taylor & Francis
Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
Genome modeling: from chromatin fibers to genes
The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …
many creative modeling studies. The specific model/simulation technique combination …
Design principles of 3D epigenetic memory systems
Cells remember their identities, in part, by using epigenetic marks—chemical modifications
placed along the genome. How can mark patterns remain stable over cell generations …
placed along the genome. How can mark patterns remain stable over cell generations …
[HTML][HTML] Multiscale modeling of genome organization with maximum entropy optimization
ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …
role in all DNA-templated processes, including gene transcription, gene regulation, and …
[HTML][HTML] The impact of chromatin on double-strand break repair: Imaging tools and discoveries
MAE van Bueren, A Janssen - DNA repair, 2024 - Elsevier
Eukaryotic nuclei are constantly being exposed to factors that break or chemically modify the
DNA. Accurate repair of this DNA damage is crucial to prevent DNA mutations and maintain …
DNA. Accurate repair of this DNA damage is crucial to prevent DNA mutations and maintain …
When force met fluorescence: single-molecule manipulation and visualization of protein–DNA interactions
Myriad DNA-binding proteins undergo dynamic assembly, translocation, and conformational
changes while on DNA or alter the physical configuration of the DNA substrate to control its …
changes while on DNA or alter the physical configuration of the DNA substrate to control its …
A potent, selective CBX2 chromodomain ligand and its cellular activity during prostate cancer neuroendocrine differentiation
Polycomb group (PcG) proteins are epigenetic regulators that facilitate both embryonic
development and cancer progression. PcG proteins form Polycomb repressive complexes 1 …
development and cancer progression. PcG proteins form Polycomb repressive complexes 1 …
[HTML][HTML] H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape
N Furth, D Algranati, B Dassa, O Beresh, V Fedyuk… - Cell Reports, 2022 - cell.com
Cancer-associated mutations in genes encoding histones dramatically reshape chromatin
and support tumorigenesis. Lysine to methionine substitution of residue 27 on histone H3 …
and support tumorigenesis. Lysine to methionine substitution of residue 27 on histone H3 …
Oncohistones: hijacking the histone code
V Sahu, C Lu - Annual review of cancer biology, 2022 - annualreviews.org
Chromatin dysfunction has been implicated in a growing number of cancers especially in
children and young adults. In addition to chromatin-modifying and-remodeling enzymes …
children and young adults. In addition to chromatin-modifying and-remodeling enzymes …
Explicit ion modeling predicts physicochemical interactions for chromatin organization
Molecular mechanisms that dictate chromatin organization in vivo are under active
investigation, and the extent to which intrinsic interactions contribute to this process remains …
investigation, and the extent to which intrinsic interactions contribute to this process remains …