The identification of systemic inflammation (SI) as a central player in the orchestration of
acute‐on‐chronic liver failure (ACLF) has opened new avenues for the understanding of the …

Abstract Alpha1-antitrypsin deficiency (AATD) is a rare autosomal recessive disease
associated with the homozygous Z variant of the SERPINA1 gene. Clinical expression of …

Background & Aims Alpha-1 antitrypsin (AAT) deficiency causes/predisposes individuals to
advanced chronic liver disease (ACLD). However, the role of the SERPINA1 Pi∗ Z allele in …

Background SerpinB3 is a cysteine protease inhibitor involved in liver disease progression
due to its proinflammatory and profibrogenic properties. The polymorphic variant SerpinB3 …

Alpha-1 antitrypsin deficiency (AATD) arises due to inherited variants in SERPINA1, the AAT
gene that impairs the production or secretion of this hepatocellular protein and leads to a …

Cleaning up alpha-1 antitrypsin deficiency related liver dis... : Current Opinion in
Gastroenterology Cleaning up alpha-1 antitrypsin deficiency related liver disease : Current …

Background and Aims Homozygous Pi∗ Z mutation in alpha-1 antitrypsin (Pi∗ ZZ genotype)
predisposes to pulmonary loss-of-function and hepatic gain-of-function injury. To facilitate …

Abstract Background and Aims The course of adults with ZZ alpha‐1‐antitrypsin deficiency
(AATD) liver disease is unpredictable. The utility of markers, including liver biopsy, is …

Background: The PNPLA3-rs738409-G, TM6SF2-rs58542926-T, and HSD17B13-rs6834314-
A polymorphisms have been associated with cirrhosis, hepatic decompensation, and HCC …

Background Alpha‐1 antitrypsin liver disease (AATLD) occurs in a subset of patients with
alpha‐1 antitrypsin deficiency. Risk factors for disease progression and specific …