The increased application of transcriptome-wide profiling approaches has led to an
explosion in the number of documented long non-coding RNAs (lncRNAs). While these new …

Meiotic recombination involves the formation and repair of programmed DNA double-strand
breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent …

Meiosis, the mechanism of creating haploid gametes, is a complex cellular process
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …

Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be
fully ascertained. We have constructed a first-generation CNV map of the human genome …

We describe the Phase II HapMap, which characterizes over 3.1 million human single
nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically …

Recombination is a fundamental biological process with profound evolutionary implications.
Theory predicts that recombination increases the effectiveness of selection in natural …

DNA-binding transcriptional regulators interpret the genome's regulatory code by binding to
specific sequences to induce or repress gene expression. Comparative genomics has …

The nonrandom distribution of meiotic recombination influences patterns of inheritance and
genome evolution, but chromosomal features governing this distribution are poorly …

Mammalian genomes employ heritable cytosine methylation in the long-term silencing of
retrotransposons and genes subject to genomic imprinting and X chromosome inactivation …

Genetic maps, which document the way in which recombination rates vary over a genome,
are an essential tool for many genetic analyses. We present a high-resolution genetic map …