Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

M Gao, F Yu, C Lv, J Choo, L Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

Photoresponsive biomaterials for targeted drug delivery and 4D cell culture

ER Ruskowitz, CA DeForest - Nature Reviews Materials, 2018 - nature.com
Biological signalling is regulated through a complex and tightly choreographed interplay
between cells and their extracellular matrix. The spatiotemporal control of these interactions …

Reactive‐oxygen‐species‐responsive drug delivery systems: promises and challenges

G Saravanakumar, J Kim, WJ Kim - Advanced Science, 2017 - Wiley Online Library
Given the increasing evidence indicates that many pathological conditions are associated
with elevated reactive oxygen species (ROS) levels, there have been growing research …

Small conjugate-based theranostic agents: an encouraging approach for cancer therapy

R Kumar, WS Shin, K Sunwoo, WY Kim… - Chemical Society …, 2015 - pubs.rsc.org
The advances in genomics, proteomics, and bioinformatics have directed the development
of new anticancer agents to reduce drug abuse and increase safe and specific drug …

[HTML][HTML] ROS-responsive drug delivery systems for biomedical applications

W Tao, Z He - asian journal of pharmaceutical sciences, 2018 - Elsevier
In the field of biomedicine, stimuli-responsive drug delivery systems (DDSs) have become
increasingly popular due to their site-specific release ability in response to a certain …

Conjugates of porphyrinoid-based photosensitizers with cytotoxic drugs: current progress and future directions toward selective photodynamic therapy

VF Otvagin, NS Kuzmina, ES Kudriashova… - Journal of medicinal …, 2022 - ACS Publications
Photodynamic therapy (PDT) is a treatment modality where light-mediated activation of
photosensitizers in a patient's body leads to the generation of cytotoxic reactive oxygen …

A near-IR uncaging strategy based on cyanine photochemistry

AP Gorka, RR Nani, J Zhu, S Mackem… - Journal of the …, 2014 - ACS Publications
The development of photocaging groups activated by near-IR light would enable new
approaches for basic research and allow for spatial and temporal control of drug delivery …

ROS‐responsive drug delivery systems

J Liang, B Liu - Bioengineering & translational medicine, 2016 - Wiley Online Library
Reactive oxygen species (ROS) play an important role in signal transduction and
metabolism. Over‐produced ROS in cells or tissues, however, often leads to oxidation stress …

Near‐IR light‐mediated cleavage of antibody–drug conjugates using cyanine photocages

RR Nani, AP Gorka, T Nagaya… - Angewandte Chemie …, 2015 - Wiley Online Library
Despite significant progress in the clinical application of antibody drug conjugates (ADCs),
novel cleavage strategies that provide improved selectivity are still needed. Herein is …

The good, the bad, and the ugly–controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

S Callaghan, MO Senge - Photochemical & photobiological sciences, 2018 - pubs.rsc.org
Singlet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable,
suffers from poor selectivity and has fast decomposition rates in biological media. Across the …