Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Ever since Linus Pauling published his studies, the effects of vitamin C have been
surrounded by contradictory results. This may be because its effects depend on a number of …

Significance: Vitamin C, or ascorbic acid, has long been known to participate in several
important functions in the vascular bed in support of endothelial cells. These functions …

Ascorbate (vitamin C) is a vital antioxidant molecule in the brain. However, it also has a
number of other important functions, participating as a cofactor in several enzyme reactions …

Vitamin C is accumulated in mammalian cells by two types of proteins: sodium-ascorbate co-
transporters (SVCTs) and hexose transporters (GLUTs); in particular, SVCTs actively import …

Vitamin C, or ascorbic acid, is important as an antioxidant and participates in numerous
cellular functions. Although it circulates in plasma in micromolar concentrations, it reaches …

Ascorbic acid is a key antioxidant of the Central Nervous System (CNS). Under brain activity,
ascorbic acid is released from glial reservoirs to the synaptic cleft, where it is taken up by …

It has been proposed that the enhanced metabolic activity of tumor cells is accompanied by
an increased expression of facilitative hexose transporters (GLUTs). However, a previous …

The mechanisms allowing the cellular transport of ascorbic acid represent a primary aspect
for the understanding of the roles played by this vitamin in pathophysiology. Considerable …

Large cross-sectional population studies confirm that vitamin C deficiency is common in
humans, affecting 5%–10% of adults in the industrialized world. Moreover, significant …