Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

The world is facing the new challenges of an aging population, and understanding the
process of aging has therefore become one of the most important global concerns …

Skeletal muscle fibers are classified into fiber types, in particular, slow twitch versus fast
twitch. Muscle fiber types are generally defined by the particular myosin heavy chain …

Skeletal muscle fitness and plasticity is an important determinant of human health and
disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by …

Obesity can cause a decline in contractile function of skeletal muscle, thereby reducing
mobility and promoting obesity-associated health risks. We reviewed the literature to …

Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …

Chronic inflammation and fibrosis characterize Duchenne muscular dystrophy (DMD). We
show that pro-inflammatory macrophages are associated with fibrosis in mouse and human …

Current molecular genomic approaches to human genetic disorders have led to an
explosion in the identification of the genes and their encoded proteins responsible for these …

In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions
such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell …

Highlights•Numerous pathophysiological features of DMD provide different therapeutic
avenues.•Pharmacolougical therapies target all muscles and are applicable to all DMD …