Myelin consists of tightly compacted membranes that form an insulating sheath around
axons. The function of myelin for rapid saltatory nerve conduction is dependent on its unique …

Simple Summary The use of biomarkers can provide information about the outcome of
cancer patients, the type of tumor, its malignant potential and the risk of recurrence, and may …

Proteome and transcriptome analyses aim at comprehending the molecular profiles of the
brain, its cell-types and subcellular compartments including myelin. Despite the relevance of …

Peripheral nerve myelin facilitates rapid impulse conduction and normal motor and sensory
functions. Many aspects of myelin biogenesis, glia–axonal interactions, and nerve …

The formation of central nervous system myelin by oligodendrocytes requires sterol
synthesis and is associated with a significant enrichment of cholesterol in the myelin …

A bottleneck in high-throughput functional genomics experiments is identifying the most
important genes and their relevant functions from a list of gene hits. Gene Ontology (GO) …

Tight junctions are complex membrane structures that regulate paracellular movement of
material across epithelia and play a role in cell polarity, signaling and cytoskeletal …

Rapid impulse conduction requires electrical insulation of axons by myelin, a cholesterol-
rich extension of the glial cell membrane with a characteristic composition of proteins and …

Mouse deafness mutations provide valuable models of human hearing disorders and entry
points into molecular pathways important to the hearing process. A newly discovered mouse …

Epithelial organs develop through tightly coordinated events of cell proliferation and
differentiation in which endocytosis plays a major role. Despite recent advances, how …