The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …

Cell size is tightly controlled in healthy tissues, but it is unclear how deviations in cell size
affect cell physiology. To address this, we measured how the cell's proteome changes with …

The human body is programmed with definite quantities, magnitudes, and proportions. At the
microscopic level, such definite sizes manifest in individual cells-different cell types are …

Cell dry mass is principally determined by the sum of biosynthesis and degradation.
Measurable change in dry mass occurs on a time scale of hours. By contrast, cell volume …

Cell size is tightly controlled in healthy tissues and single-celled organisms, but it remains
unclear how cell size influences physiology. Increasing cell size was recently shown to …

Mammalian cells make the decision to divide at the G1-S transition in response to diverse
signals impinging on the retinoblastoma protein Rb, a cell cycle inhibitor and tumor …

Cell mass and composition change with cell cycle progression. Our previous work
characterized buoyant mass dynamics in mitosis (Miettinen et al., 2019), but how dry mass …

Increasing cell size drives changes to the proteome, which affects cell physiology. As cell
size increases, some proteins become more concentrated while others are diluted. As a …

Accurate measurements of the molecular composition of single cells will be necessary for
understanding the relationship between gene expression and function in diverse cell types …

Every type of cell in an animal maintains a specific size, which likely contributes to its ability
to perform its physiological functions. While some cell size control mechanisms are …