The pericardium, which surrounds the heart, provides a unique enclosed volume and a site
for the delivery of agents to the heart and coronary arteries. While strategies for targeting the …

Adenosine and inosine are believed to have cardioprotective effects. However, little is
known about their possible role in the metabolic autoregulation of human coronaries and in …

There is epidemiologic evidence that the prognosis of patients with nonischemic heart
failure is better than that for patients with ischemic heart failure. In addition, studies have …

It has been shown that the adenosine concentration in the pericardial fluid of the normal
heart is higher by one order of magnitude than that of the venous plasma. A further increase …

Pericardial fluid accumulates the cardioprotective purine metabolites, as well as the
endogenous vasoconstrictor agent endothelin-1 (ET-1). The aim of the present study was to …

It has recently been proposed that endothelin-1 (ET-1) is an important activator of natriuretic
peptide [atrial natriuretic peptide (ANP) and the brain natriuretic peptide (BNP)] release in …

Recently, several vasoactive molecules have been found in pericardial fluid (PF). Thus, we
hypothesized that in coronary artery disease due to ischemia or ischemia–reperfusion, the …

The pericardial fluid may accumulate endogenous regulatory agents, such as
catecholamines, endothelin or adenine nucleosides. However, very little information is …

In earlier studies severe ventricular arrhythmias developed during intrapericardial (ip.)
endothelin-1 (ET-1) infusion. Monophasic action potential duration (MAPD90) increase and …

Talán senki nem gondolta, hogy a társadalom bűnözés elleni küzdelmében Sherlock
Holmes régi axiómáját, miszerint „the little things are infinitely the most important”, egy …