Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy

KDR Roth, EV Wenzel, M Ruschig, S Steinke… - Frontiers in cellular …, 2021 - frontiersin.org
Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …

Applications of the phage display technology in molecular biology, biotechnology and medicine

K Pierzynowska, J Morcinek-Orłowska… - Critical Reviews in …, 2024 - Taylor & Francis
The phage display technology is based on the presentation of peptide sequences on the
surface of virions of bacteriophages. Its development led to creation of sophisticated systems …

Generation and analysis of the improved human HAL9/10 antibody phage display libraries

J Kügler, S Wilke, D Meier, F Tomszak, A Frenzel… - BMC …, 2015 - Springer
Background Antibody phage display is a proven key technology that allows the generation
of human antibodies for diagnostics and therapy. From naive antibody gene libraries-in …

Addressing barriers to the development and adoption of rapid diagnostic tests in global health

E Miller, HD Sikes - Nanobiomedicine, 2015 - hrcak.srce.hr
Sažetak Immunochromatographic rapid diagnostic tests (RDTs) have demonstrated
significant potential for use as point-of-care diagnostic tests in resource-limited settings …

A simple, sensitive and reduced cost paper-based device with low quantity of chemicals for the early diagnosis of Plasmodium falciparum malaria using an enzyme …

GP dos Santos, CC Corrêa, LT Kubota - Sensors and Actuators B …, 2018 - Elsevier
In this study, we report the development of a paper-based platform with low amount of
reagents for the detection of the histidine-rich protein 2 by an enzyme-based colorimetric …

Activity-based assessment of an engineered hyperthermophilic protein as a capture agent in paper-based diagnostic tests

EA Miller, MW Traxlmayr, J Shen… - Molecular systems design …, 2016 - pubs.rsc.org
Antibodies have traditionally served as the affinity reagents of choice in point-of-care
diagnostic biosensors. However, this class of proteins is not ideally suited for this use, being …

Naive human antibody libraries for infectious diseases

SK Chan, A Rahumatullah, JY Lai, TS Lim - Recombinant Antibodies for …, 2017 - Springer
Many countries are facing an uphill battle in combating the spread of infectious diseases.
The constant evolution of microorganisms magnifies the problem as it facilitates the re …

Isolation and Characterization of Targeting-HBsAg VNAR Single Domain Antibodies from Whitespotted Bamboo Sharks (Chiloscyllium plagiosum)

X Jiang, S Sun, Z Li, M Chen - Marine Drugs, 2023 - mdpi.com
Immunoglobulin new antigen receptor (IgNAR) is a naturally occurring antibody that consists
of only two heavy chains with two independent variable domains. The variable binding …

[HTML][HTML] Insights into the performance of SD Bioline Malaria Ag Pf/Pan rapid diagnostic test and Plasmodium falciparum histidine-rich protein 2 gene variation in …

N Willie, RK Mehlotra, RE Howes… - The American journal …, 2018 - ncbi.nlm.nih.gov
Plasmodium falciparum histidine-rich protein 2 (PfHRP2) forms the basis of many current
malaria rapid diagnostic tests (RDTs). However, the parasites lacking part or all of the pfhrp2 …

Development and Characterization of Anti-Naja ashei Three-Finger Toxins (3FTxs)-Specific Monoclonal Antibodies and Evaluation of Their In Vitro Inhibition Activity

EZ Manson, MC Kyama, J Kimani, A Bocian, KK Hus… - Toxins, 2022 - mdpi.com
Antivenom immunotherapy is the mainstay of treatment for snakebite envenoming. Most
parts of the world affected by snakebite envenoming depend on broad-spectrum polyspecific …