The long-term survival of any multicellular species depends on the success of its germline in
producing high-quality gametes and maximizing survival of the offspring. Studies in …

Proper differentiation of sperm from germline stem cells, essential for production of the next
generation, requires dramatic changes in gene expression that drive remodeling of almost …

The septate junction (SJ) provides an occluding function for epithelial tissues in invertebrate
organisms. This ability to seal the paracellular route between cells allows internal tissues to …

Given their copy number differences and unique modes of inheritance, the evolved gene
content and expression of sex chromosomes is unusual. In many organisms the X and Y …

Stem cells reside in and rely upon their niche to maintain stemness but must balance self-
renewal with the production of daughters that leave the niche to differentiate. We discovered …

Stem cells typically reside in a specialized physical and biochemical environment that
facilitates regulation of their behavior. For this reason, stem cells are ideally studied in …

Two different compartments support germline stem cell (GSC) self-renewal and their timely
differentiation: the classical niche provides maintenance cues, while a differentiation …

Stem cells often rely on signals from a niche, which in many tissues adopts a precise
morphology. What remains elusive is how niches are formed and how morphology impacts …

Soma-germline interactions play conserved essential roles in regulating cell proliferation,
differentiation, patterning and homeostasis in the gonad. In the Drosophila testis, secreted …

Stem cells reside in niches that provide signals to maintain self-renewal, and differentiation
is viewed as a passive process that depends on loss of access to these signals. Here, we …