Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Epithelial-to-mesenchymal transitions (EMT) and unjamming transitions provide two distinct
pathways for cancer cells to become invasive, but it is still unclear to what extent these …

Invasion of some cancer cells into surrounding tissues requires traversing dense
environments, although the precise mechanisms are unclear. In this issue of Developmental …

Epithelial ovarian cancer (EOC) is characterized by resistance to platinum-based therapy,
resulting in rapid progression and poor survival. Here, we ask whether drug resistance and …

Cellular plasticity is a hallmark function of cancer, but many of the underlying mechanisms
are not well understood. We uncover Caveolin-1, a scaffolding protein that modulates …

In migrating cells, the GTPase Rac organizes a protrusive front, whereas Rho organizes a
contractile back. How these GTPases are appropriately positioned at the opposite poles of a …

Cells rely on substrate adhesion to activate diverse signaling pathways essential for
survival. In the absence of proper adhesion, cells undergo anoikis, a form of programmed …

Despite recent experimental progress in characterizing cell migration mechanics, our
understanding of the mechanisms governing rapid cell movement remains limited. To …