Mechanistic pathogenesis of endothelial dysfunction in diabetic nephropathy and retinopathy

J Yang, Z Liu - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

Quercetin: An effective polyphenol in alleviating diabetes and diabetic complications

L Yan, M Vaghari-Tabari, F Malakoti… - Critical reviews in …, 2023 - Taylor & Francis
Various studies, especially in recent years, have shown that quercetin has beneficial
therapeutic effects in various human diseases, including diabetes. Quercetin has significant …

The role of inflammation in immune system of diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications

T Yue, Y Shi, S Luo, J Weng, Y Wu… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy is one of the most common complications of diabetes mellitus and the
leading cause of low vision and blindness worldwide. Mounting evidence demonstrates that …

The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with …

K Siddiqui, TP George, M Mujammami… - Frontiers in …, 2023 - frontiersin.org
Objective Chronic hyperglycemia induces pathogenic changes in the vascular endothelium
and leads to the development of microvascular complications in patients with type 2 …

Recent trends in drug-delivery systems for the treatment of diabetic retinopathy and associated fibrosis

M Silva, T Peng, X Zhao, S Li, M Farhan… - Advanced Drug Delivery …, 2021 - Elsevier
Diabetic retinopathy is a frequent microvascular complication of diabetes and a major cause
of visual impairment. In advanced stages, the abnormal neovascularization can lead to …

[HTML][HTML] Pathogenesis of diabetic complications: Exploring hypoxic niche formation and HIF-1α activation

J Bi, W Zhou, Z Tang - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Hypoxia is a common feature of diabetic tissues, which highly correlates to the progression
of diabetes. The formation of hypoxic context is induced by disrupted oxygen homeostasis …

Protective effects of fucoxanthin on high glucose-and 4-hydroxynonenal (4-HNE)-induced injury in human retinal pigment epithelial cells

YF Chiang, HY Chen, YJ Chang, YH Shih, TM Shieh… - Antioxidants, 2020 - mdpi.com
The incidence of diabetes mellitus is increasing due to the eating and living habits of
modern people. As the disease progresses, the long-term effects of diabetes can cause …

Neutrophils and their role in the aetiopathogenesis of type 1 and type 2 diabetes

A Giovenzana, D Carnovale, B Phillips… - Diabetes/Metabolism …, 2022 - Wiley Online Library
Multiple and complex aetiological processes underlie diabetes mellitus, which invariably
result in the development of hyperglycaemia. Although there are two prevalent distinct forms …

Single‐cell immune profiling in coronary artery disease: The role of state‐of‐the‐art immunophenotyping with mass cytometry in the diagnosis of atherosclerosis

KA Kott, ST Vernon, T Hansen, M de Dreu… - Journal of the …, 2020 - Am Heart Assoc
Coronary artery disease remains the leading cause of death globally and is a major burden
to every health system in the world. There have been significant improvements in risk …

[HTML][HTML] VEGF promotes diabetic retinopathy by upregulating the PKC/ET/NF-κB/ICAM-1 signaling pathway

M Zhang, M Zhou, X Cai, Y Zhou, X Jiang… - European Journal of …, 2022 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) is a common microvascular complication in patients with diabetes
mellitus. DR is caused by chronic hyperglycemia and characterized by progressive loss of …