Cluster headache is a debilitating primary headache disorder that affects approximately
0.1% of the population worldwide. Cluster headache attacks involve severe unilateral pain …

There is substantial evidence indicating a role for glutamate in migraine. Levels of glutamate
are higher in the brain and possibly also in the peripheral circulation in migraine patients …

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta …

Principles of complex mechanisms of action of anticonvulsants including latest reports
concerning new antiepileptic drugs (AED) are considered. Different aspects of new …

Background In evidence‐based guidelines published in 2000, topiramate was a third‐tier
migraine preventive with no scientific evidence of efficacy; recommendation for its use …

Pathologic alcohol use affects more than 2 billion people and accounts for nearly 6% of all
deaths worldwide. There are three medications approved for the treatment of alcohol use …

Post-traumatic stress disorder (PTSD) is a disabling psychiatric condition with a critical
familiar, personal, and social impact. Patients diagnosed with PTSD show various …

Patients experiencing mental disorders are at an elevated risk for developing aggressive
behavior. In the past 10 years, the psychopharmacological treatment of aggression has …

Topiramate (TPM; TOPAMAX®) is a broad‐spectrum antiepileptic drug (AED) that is
approved in many world markets for preventing or reducing the frequency of epileptic …

Background: A dysfunction in glutamate neurotransmission is critical for seizure. Glutamate
is the major excitatory drive in the cerebral cortex, where seizures occur. Glutamate acts via …