A formal demonstration that mammalian pluripotent stem cells possess preimplantation
embryonic cell-like (naive) pluripotency is the generation of chimeric animals through early …

Fragile X encompasses a range of genetic conditions, all of which result as a function of
changes within the FMR1 gene and abnormal production and/or expression of the FMR1 …

Embryogenesis necessitates harmonious coordination between embryonic and
extraembryonic tissues. Although stem cells of both embryonic and extraembryonic origins …

Organ transplantation is the most promising curation for end-stage organ disease. However,
the donor organ shortage has become a global problem that has limited the development of …

Blastocyst complementation by pluripotent stem cell (PSC) injection is believed to be the
most promising method to generate xenogeneic organs. However, ethical issues prevent the …

After reprogramming to naive pluripotency, human pluripotent stem cells (PSCs) still exhibit
very low ability to make interspecies chimeras. Whether this is because they are inherently …

Human primed embryonic stem cells (ESCs) are known to be converted to cells with several
trophoblast properties, but it has remained controversial whether this phenomenon …

Recent advances in stem cell biology and molecular engineering have improved and
simplified the methodology employed to create experimental chimeras, highlighting their …

Non-human primates (NHPs) are increasingly used in preclinical trials to test the safety and
efficacy of biotechnology therapies. Nonetheless, given the ethical issues and costs …

Elevated levels of endogenous ovarian hormones are conditions commonly experienced by
women undergoing assisted reproductive technologies (ART). Additionally, infertility …