[HTML][HTML] SDH mutations in cancer

C Bardella, PJ Pollard, I Tomlinson - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate
dehydrogenase (SDH; mitochondrial complex II), a mitochondrial enzyme involved in two …

SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma–paraganglioma syndromes

B Pasini, CA Stratakis - Journal of internal medicine, 2009 - Wiley Online Library
A genetic predisposition for paragangliomas and adrenal or extra‐adrenal
phaeochromocytomas was recognized years ago. Beside the well‐known syndromes …

Pheochromocytoma and paraganglioma: understanding the complexities of the genetic background

L Fishbein, KL Nathanson - Cancer genetics, 2012 - Elsevier
Pheochromocytomas and paragangliomas (PCC/PGL) are tumors derived from the adrenal
medulla or extra-adrenal ganglia, respectively. They are rare and often benign tumors that …

The molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors

CA Koch, K Pacak, GP Chrousos - The Journal of Clinical …, 2002 - academic.oup.com
Modern imaging modalities lead to frequent detection of adrenal masses, most of them
incidental findings. Although the majority of adrenocortical and adrenomedullary tumors are …

Somatic loss of maternal chromosome 11 causes parent-of-origin-dependent inheritance in SDHD-linked paraganglioma and phaeochromocytoma families

EF Hensen, ES Jordanova, IJHM van Minderhout… - Oncogene, 2004 - nature.com
Germline mutations in succinate dehydrogenase subunits B, C and D (SDHB, SDHC and
SDHD), genes encoding subunits of mitochondrial complex II, cause hereditary …

Genetics of pheochromocytomas and paragangliomas

G Opocher, F Schiavi - Best practice & research Clinical endocrinology & …, 2010 - Elsevier
Pheochromocytoma and paraganglioma are tumors of the sympathetic or parasympathetic
paraganglia. Pheochromocytoma is the tumor of the main sympathetic paraganglia, which is …

The genetic basis of pheochromocytoma

O Gimm, CA Koch, A Januszewicz, G Opocher… - …, 2004 - karger.com
Historically, pheochromocytoma has been referred to as the 10% tumor, ie 10% were
believed to be hereditary, 10% were found to be extra-adrenal, and 10% were considered to …

[HTML][HTML] MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas

Z Tömböl, K Eder, A Kovács, PM Szabo, J Kulka, I Liko… - Modern Pathology, 2010 - Elsevier
MicroRNAs are involved in the pathogenesis of several tumors, however, there have been
no data on microRNA expression in pheochromocytomas to date. The objective of our study …

Malignant pheochromocytomas and paragangliomas: a diagnostic challenge

O Gimm, C DeMicco, A Perren, F Giammarile… - … archives of surgery, 2012 - Springer
Abstract Introduction Malignant pheochromocytomas (PCCs) and paragangliomas (PGLs)
are rare disorders arising from the adrenal gland, from the glomera along parasympathetic …

Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DCR1, DCR2, DR4, DR5, KvDMR1, H19 and preferential 11p15. 5 maternal-allele loss in von Hippel-Lindau and …

CDE Margetts, D Astuti, DC Gentle… - Endocrine-Related …, 2005 - erc.bioscientifica.com
Phaeochromocytoma is a neural-crest-derived tumour that may be a feature of several
familial cancer syndromes including von Hippel-Lindau (VHL) disease, multiple endocrine …