Physiological and pathophysiological roles of NAMPT and NAD metabolism

A Garten, S Schuster, M Penke, T Gorski… - Nature Reviews …, 2015 - nature.com
Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular
nicotinamide adenine dinucleotide (NAD) pool. NAD is an essential coenzyme involved in …

Nicotinamide mononucleotide: a promising molecule for therapy of diverse diseases by targeting NAD+ metabolism

W Hong, F Mo, Z Zhang, M Huang… - Frontiers in cell and …, 2020 - frontiersin.org
NAD+, a co-enzyme involved in a great deal of biochemical reactions, has been found to be
a network node of diverse biological processes. In mammalian cells, NAD+ is synthetized …

Notoginseng Leaf Triterpenes Ameliorates OGD/R‐Induced Neuronal Injury via SIRT1/2/3‐Foxo3a‐MnSOD/PGC‐1α Signaling Pathways Mediated by the NAMPT …

W Xie, T Zhu, P Zhou, H Xu, X Meng… - Oxidative Medicine …, 2020 - Wiley Online Library
Background. Cerebral ischemic stroke (CIS) is a common cerebrovascular disease whose
main risks include necrosis, apoptosis, and cerebral infarction. But few therapeutic advances …

Regulation and function of extracellular nicotinamide phosphoribosyltransferase/visfatin

F Carbone, L Liberale, A Bonaventura… - Comprehensive …, 2011 - Wiley Online Library
Nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine‐enzyme, which was
described as to play bioactivities both in the intracellular and in the extracellular …

NAMPT as a therapeutic target against stroke

P Wang, CY Miao - Trends in Pharmacological Sciences, 2015 - cell.com
Nicotinamide phosphoribosyltransferase (NAMPT), also an adipokine known as visfatin, acts
via enzymatic activity to synthesize nicotinamide mononucleotide (NMN) and then to …

Inflammatory processes in obesity: focus on endothelial dysfunction and the role of adipokines as inflammatory mediators: We reviewed obesity-induced metabolic …

M Singh, F Benencia - International reviews of immunology, 2019 - Taylor & Francis
Obesity predisposes the affected individuals to several metabolic, inflammatory,
cardiovascular and malignant pathologies and is a top risk factor for premature mortality. It is …

Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives

F Wen, G Gui, X Wang, L Ye, A Qin, C Zhou… - Bioorganic & Medicinal …, 2024 - Elsevier
Nicotinamide phosphoribosyltransferase (NAMPT) is a key rate-limiting enzyme in the
nicotinamide adenine dinucleotide (NAD+) salvage pathway, primarily catalyzing the …

Non-canonical roles of NAMPT and PARP in inflammation

FJ Martínez-Morcillo, J Cantón-Sandoval… - Developmental & …, 2021 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is the most important hydrogen carrier in cell
redox reactions. It is involved in mitochondrial function and metabolism, circadian rhythm …

Effects of the Combination of the Main Active Components of Astragalus and Panax notoginseng on Inflammation and Apoptosis of Nerve Cell after Cerebral …

XP Huang, H Ding, JD Lu, YH Tang… - The American journal …, 2015 - World Scientific
Astragalus and Panax notoginseng are commonly used to treat cardio-cerebrovascular
diseases in China and are often combined together to promote curative effect. We speculate …

Extracellular visfatin has nicotinamide phosphoribosyltransferase enzymatic activity and is neuroprotective against ischemic injury

Y Zhao, XZ Liu, WW Tian, YF Guan… - CNS neuroscience & …, 2014 - Wiley Online Library
Aim Visfatin, a novel adipokine, is predominantly produced by visceral adipose tissue and
exists in intracellular and extracellular compartments. The intracellular form of visfatin is …