Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which
exhibit some symptom similarities and are thus considered to share a common etiology. The …

Background The role of inflammation and cytokines in the pathophysiology of primary
headache disorders is uncertain. We performed a systematic review and meta-analysis to …

Background Cytokines are important endogenous substances that are involved in immune
and inflammatory responses. Neurogenic inflammation has been proposed to play a role in …

Migraine is one of the most prevalent and disabling neurovascular disorders worldwide.
However, despite the increase in awareness and research, the understanding of migraine …

Currently, migraine is treated mainly by targeting calcitonin gene-related peptides, although
the efficacy of this method is limited and new treatment strategies are desired …

Migraine is the most common neurological disorder in the world, affecting 12% of the
population. Migraine involves the central nervous system, trigeminal nerves and meninges …

Introduction As a primary headache, migraine has been established as the first leading
disability cause worldwide in the subjects who aged less than 50 years. A variety of dietary …

Several lines of evidence support a role of the immune system in headache pathogenesis,
with particular regard to migraine. Firstly, alterations in cytokine profile and in lymphocyte …

The exact mechanism of the migraine pathophysiology remained unclear. Although there
are some reports showing low-grade inflammation in migraineurs, further studies are …

Experimental findings suggest an involvement of neuroinflammatory mechanisms in the
pathophysiology of migraine. Specifically, preclinical models of migraine have emphasized …