Since the identification of the first SCN5A mutation associated with long QT syndrome in
1995, several mutations in this gene for the α subunit of the cardiac sodium channel have …

Rapid inactivation of sodium channels is crucial for the normal electrical activity of excitable
cells. There are many different types of inactivation, including fast, slow and ultra-slow, and …

Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …

Sick sinus syndrome (SSS) describes an arrhythmia phenotype attributed to sinus node
dysfunction and diagnosed by electrocardiographic demonstration of sinus bradycardia or …

INTRODUCTION Members of the voltage-gated sodium (Nav) channel family are critical
contributors to electrical signaling. Accordingly, they are targets of drugs, toxins, and …

Partial or complete loss-of-function variants in SCN5A are the most common genetic cause
of the arrhythmia disorder Brugada syndrome (BrS1). However, the pathogenicity of SCN5A …

Nav1. 5 is the primary voltage-gated Na+ (Nav) channel in the heart. Mutations of Nav1. 5
are associated with various cardiac disorders exemplified by the type 3 long QT syndrome …

Infusion of the chemotherapeutic agent oxaliplatin leads to an acute and a chronic form of
peripheral neuropathy. Acute oxaliplatin neuropathy is characterized by sensory …

Objectives: We sought to assess differences in phenotype and prognosis between men and
women in a large population of patients with Brugada syndrome. Background: A male …

Sudden unexplained nocturnal death syndrome (SUNDS), a disorder found in southeast
Asia, is characterized by an abnormal electrocardiogram with ST-segment elevation in leads …