Immune checkpoint inhibitor associated myocarditis and cardiomyopathy: a translational review

D Wang, J Bauersachs, D Berliner - Biology, 2023 - mdpi.com
Simple Summary Immune checkpoint inhibitors (ICIs) are novel cancer therapeutics that
address the immune system to attack malignancies. While this therapy has significantly …

Immune checkpoint inhibitors associated cardiovascular immune-related adverse events

W Jo, T Won, A Daoud, D Čiháková - Frontiers in immunology, 2024 - frontiersin.org
Immune checkpoint inhibitors (ICIs) are specialized monoclonal antibodies (mAbs) that
target immune checkpoints and their ligands, counteracting cancer cell-induced T-cell …

Immune checkpoint inhibitors—Associated cardiotoxicity

C Li, SA Bhatti, J Ying - Cancers, 2022 - mdpi.com
Simple Summary With nonspecific activation of the immune system, immune checkpoint
inhibitors (ICIs) can lead to off-target immune-related adverse events (irAEs) to every organ …

A retrospective cohort study on the cardiotoxicity incidence rates of immune checkpoint inhibitors for oncology patients

CC Ho, SL Wu, HY Tsai, YW Hu… - Journal of the Chinese …, 2023 - journals.lww.com
Background: This present study investigated the incidence rates of cardiotoxicity among
cancer patients treated with immune checkpoint inhibitors (ICIs) plus other anticancer drugs …

[HTML][HTML] Predicting cardiac adverse events in patients receiving immune checkpoint inhibitors: a machine learning approach

SP Heilbroner, R Few, TG Neilan… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Treatment with immune checkpoint inhibitors (ICIs) has been associated with
an increased rate of cardiac events. There are limited data on the risk factors that predict …

Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure

TG Gergely, ZD Drobni, M Kallikourdis, H Zhu… - Nature Reviews …, 2024 - nature.com
Immune checkpoint molecules are physiological regulators of the adaptive immune
response. Immune checkpoint inhibitors (ICIs), such as monoclonal antibodies targeting …

Incidence of immune checkpoint inhibitor mediated cardiovascular toxicity: A systematic review and meta‐analysis

MM Malaty, AT Amarasekera, C Li… - European Journal of …, 2022 - Wiley Online Library
Background Immune checkpoint inhibitors (ICI) are a novel class of anti‐cancer therapy
becoming increasingly associated with fatal cardiovascular toxicities (CVTs). The aim is to …

Immune checkpoint inhibitors and the risk of major atherosclerotic cardiovascular events in patients with high-risk or advanced melanoma: a retrospective cohort study

C Wang, S Zoungas, M Yan, R Wolfe, A Haydon… - Cardio-Oncology, 2022 - Springer
Background Immune checkpoint inhibitors (ICI) are associated with immune-mediated
adverse effects, potentially involving any organ. ICI has also been associated with an …

The diagnosis and management of immune checkpoint inhibitor cardiovascular toxicity: myocarditis and beyond

D Gilon, Z Iakobishvili, D Leibowitz - Vaccines, 2022 - mdpi.com
Recent years have brought major advancements in the use of immune therapy and
specifically immune checkpoint inhibitors (ICIs) in cancer patients, with expanding …

Comparative cardiotoxicity risk of pembrolizumab versus nivolumab in cancer patients undergoing immune checkpoint inhibitor therapy: A meta-analysis

FY Ndjana Lessomo, Z Wang, C Mukuka - Frontiers in Oncology, 2023 - frontiersin.org
Objective Recently, several researchers have reported the incidence of cardiac-related
toxicities occurring with nivolumab (Opdivo) and pembrolizumab (Keytruda). There is still a …