Genetic variability in humans is influenced by many factors, such as natural selection,
mutations, genetic drift, and migrations. Molecular epidemiology evaluates the contribution …

Multiple endocrine neoplasia type 2 (MEN2) is a neuroendocrine cancer syndrome
characterized by medullary thyroid carcinoma, in combination or not with …

Multiple endocrine neoplasia (MEN) syndromes are infrequent inherited disorders in which
more than one endocrine glands develop noncancerous (benign) or cancerous (malignant) …

Aim of the study The aim of the study was to evaluate the outcomes of prophylactic
thyroidectomies performed in an academic setting in the context of multiple endocrine …

Background Cutaneous lichen amyloidosis (CLA) has been reported in some multiple
endocrine neoplasia type 2A (MEN 2A) families affected by specific germline RET mutations …

This study systematically reviewed previous literatures and analyzed the genotype–
phenotype relationship between the multiple endocrine neoplasia type 2A (MEN 2A) …

Approximately 98% of patients with multiple endocrine neoplasia type 2A (MEN 2A) have an
identifiable RET mutation. Prophylactic or early total thyroidectomy or pheochromocytoma …

Objective A small percentage of pediatric solid cancers arise as a result of clearly identified
inherited predisposition syndromes and nongenetic lesions. Evidence supports preemptive …

Introduction Pheochromocytoma (PCC) manifests in up to 50% of MEN2 patients. We
correlated the clinico-pathological features of MEN2-associated PCC (MEN-PCC) with RET …

甲状腺髓样癌(medullary thyroid carcinoma, MTC) 属于中等恶性程度的肿瘤.
选取恰当的肿瘤标志物和相关基因对于确诊肿瘤的性质以及采取合适的手术治疗方式有重要的 …