Troponin: the biomarker of choice for the detection of cardiac injury

L Babuin, AS Jaffe - Cmaj, 2005 - Can Med Assoc
It has been known for 50 years that transaminase activity increases in patients with acute
myocardial infarction. With the development of creatine kinase (CK), biomarkers of cardiac …

Troponin elevation in heart failure: prevalence, mechanisms, and clinical implications

RD Kociol, PS Pang, M Gheorghiade… - Journal of the American …, 2010 - jacc.org
Circulating biomarkers have become increasingly important in diagnosing and risk
stratifying patients with heart failure (HF). While the natriuretic peptides have received much …

Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes

EM Antman, MJ Tanasijevic, B Thompson… - … England Journal of …, 1996 - Mass Medical Soc
Background In patients with acute coronary syndromes, it is desirable to identify a sensitive
serum marker that is closely related to the degree of myocardial damage, provides …

Human cardiac troponin complex. Structure and functions

IA Katrukha - Biochemistry (Moscow), 2013 - Springer
Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

Diseased skeletal muscle: a noncardiac source of increased circulating concentrations of cardiac troponin T

AS Jaffe, VC Vasile, M Milone, AK Saenger… - Journal of the American …, 2011 - jacc.org
Objectives: The purpose of this study was to determine whether there is immunoreactive
cardiac troponin T (cTnT) expression in diseased skeletal muscle that might cause possible …

Cardiac troponins in renal insufficiency: review and clinical implications

BJ Freda, WHW Tang, F Van Lente, WF Peacock… - Journal of the American …, 2002 - jacc.org
Patients with renal insufficiency may have increased serum troponins even in the absence of
clinically suspected acute myocardial ischemia. While cardiovascular disease is the most …

Cardiac troponins in dogs and cats

R Langhorn, JL Willesen - Journal of veterinary internal …, 2016 - Wiley Online Library
Cardiac troponins are sensitive and specific markers of myocardial injury. The troponin
concentration can be thought of as a quantitative measure of the degree of injury sustained …

Prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease: a meta-analysis

NA Khan, BR Hemmelgarn, M Tonelli, CR Thompson… - Circulation, 2005 - Am Heart Assoc
Background—The prognostic usefulness of troponin enzymes in end-stage renal disease
(ESRD) patients is controversial. To resolve this uncertainty of troponin as a prognostic tool …

Cardiac troponins

S Sharma, PG Jackson, J Makan - Journal of clinical pathology, 2004 - jcp.bmj.com
The diagnosis of myocardial infarc-tion has conventionally relied on the presence of chest
pain or typical ST segment and T wave abnormalities on the 12 lead electrocardiogram …

Circulating cardiac troponin I in severe congestive heart failure

E Missov, C Calzolari, B Pau - Circulation, 1997 - Am Heart Assoc
Background Spontaneous progression of severe congestive heart failure is structurally
characterized by cellular degeneration and multiple foci of myocardial cell death. The …