Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

In the juxtaglomerular apparatus of the kidney the loop of Henle gets into close contact to its
parent glomerulus. This anatomical link between the tubular system and the vasculature of …

Kidney blood flow and glomerular filtration rate (GFR) are maintained relatively constant by
hormonal influences and by efficient autoregulation. However, the kidney remains at risk for …

This study aims to understand the extent to which modulation of the Na+-K+-2Cl−
cotransporter NKCC2 differential splicing affects NaCl delivery to the macula densa. NaCl …

Publisher Summary This chapter focuses on the renal microcirculation. The microcirculation
of the kidney is particularly intriguing because optimum regulation of renal microcirculatory …

Recent studies show that angiotensin II stimulates the nitric oxide system via angiotensin II
type 1 and angiotensin II type 2 receptors, whereas receptors exert different effects on renal …

Interactions contributing to kidney blood flow autoregulatio... : Current Opinion in Nephrology
and Hypertension Interactions contributing to kidney blood flow autoregulation : Current Opinion …

Purinoceptors are rapidly becoming recognised as important regulators of tissue and organ
function. Renal expression of P2 receptors is broad and diverse, as reflected by the fact that …

Macula densa (MD) cells in the cortical thick ascending limb (cTAL) detect variations in
tubular fluid composition and transmit signals to the afferent arteriole (AA) that control …

Background The kidney is the main organ in the pathophysiology of essential hypertension.
Although most bicarbonate reabsorption occurs in the proximal tubule, the medullary thick …