The gene of transcriptional repressor GATA binding 1 (TRPS1), as an atypical GATA
transcription factor, has received considerable attention in a plethora of physiological and …

Phototherapy-induced hypoxia in the tumor microenvironment (TME) is responsible for
diminished therapeutic efficacy. Designing an intelligent nanosystem capable of responding …

Chemotherapy resistance accompanied by energy metabolism abnormality functions as one
of the main reasons for treatment failure and poor prognosis. However, the function of N6 …

Degenerative cervical myelopathy (DCM) is a severe condition of the spinal cord caused by
chronic compression. However, no studies to date have examined the effects of zonisamide …

Background Osteosarcoma (OS) stands out as the most common bone tumor, with
approximately 20% of the patients receiving a diagnosis of metastatic OS at their initial …

Angiogenesis plays a critical role in osteosarcoma (OS) growth and metastasis. While nerve
growth factor (NGF) is implicated in cancer progression, its role in OS angiogenesis remains …

Drug uptake into tumor cells is critical for therapeutic efficacy, and chemoresistance is a
limiting factor in therapeutic success. Chemoresistance and tumor growth are modulated by …

Background: The incidence of malignant tumors causing bone metastasis was increasing.
Therefore, it was urgent to treat patients with bone metastasis. Objectives: This study aimed …

Osteosarcoma (OS) is the most common bone tumor and 20% of the patients are diagnosed
with metastatic OS at first diagnosis. Undetectable metastases at the time of diagnosis are …