The epidermis is a self-renewing tissue. The balance between proliferation and
differentiation processes is tightly regulated to ensure the maintenance of the stem cell (SC) …

Context.—Skin neoplasms include the most common malignancies affecting humans. Many
show an ultraviolet (UV)–induced pathogenesis and often affect the head and neck region …

The immediate molecular mechanisms behind invasive melanoma are poorly understood.
Recent studies implicate microRNAs (miRNAs) as important agents in melanoma and other …

Introduction: Although widespread, BCC is still relatively poorly understood in regards to
pathogenesis and prognosis, particularly the lesions formed on anatomical sites away from …

Background Nodular melanoma (NM) is a challenge to diagnose early due to its rapid
growth and more atypical clinical presentation, making it the largest contributor to melanoma …

Background The aim of this study was to examine the role of Hh‐Gli signaling in oral and
oropharyngeal squamous cell carcinoma (SCC). The role of this signaling pathway in SCC …

Purpose Basal cell carcinoma (BCC) is the most prevalent cancer worldwide. Different
mechanisms are proposed to be involved in its pathogenesis such as oxidative stress …

The relevance of Hedgehog signaling in Merkel cell carcinoma has only been addressed by
a few studies with conflicting results. Thus, we aimed to establish the expression of …

Background The histogenesis and clinical behavior of combined cutaneous tumors (CCTs)
in which the mesenchymal component consists of melanoma remain unclear. Objective We …

In adult organisms, deregulation of the sonic hedgehog (SHH) signaling pathway is
significantly correlated with different malignancies. Currently, data associating genetic …