Reconfigurable A-motif, i-motif and triplex nucleic acids for smart pH-responsive DNA hydrogels

Y Hu, JY Ying - Materials Today, 2023 - Elsevier
Integrating dynamic reconfigurable DNA crosslinking units, smart DNA hydrogels have
demonstrated sol–gel transition, shape memory, self-healing, sensing, cargo encapsulation …

Multifunctional rolling circle transcription-based nanomaterials for advanced drug delivery

X Ma, Y Zhang, K Huang, L Zhu, W Xu - Biomaterials, 2023 - Elsevier
As the up-and-comer in the development of RNA nanotechnology, RNA nanomaterials
based on functionalized rolling circle transcription (RCT) have become promising carriers for …

Small Molecule‐Templated DNA Hydrogel with Record Stiffness Integrates and Releases DNA Nanostructures and Gene Silencing Nucleic Acids

C Lachance‐Brais, M Rammal, J Asohan… - Advanced …, 2023 - Wiley Online Library
Deoxyribonucleic acid (DNA) hydrogels are a unique class of programmable, biocompatible
materials able to respond to complex stimuli, making them valuable in drug delivery, analyte …

Biomass RNA for the Controlled Synthesis of Degradable Networks by Radical Polymerization

J Jeong, SY An, X Hu, Y Zhao, R Yin, G Szczepaniak… - ACS …, 2023 - ACS Publications
Nucleic acids extracted from biomass have emerged as sustainable and environmentally
friendly building blocks for the fabrication of multifunctional materials. Until recently, the …

Crystallinity-tuned ultrasoft polymeric DNA networks for controlled release of anticancer drugs

K Nam, YM Kim, I Choi, HS Han, T Kim, KY Choi… - Journal of Controlled …, 2023 - Elsevier
Despite the vast interest in utilizing rolling circle amplification (RCA)-based DNA networks
for bioapplications, precise control of the mechanical and physicochemical properties is …

Oligo‐Adenine Derived Secondary Nucleic Acid Frameworks: From Structural Characteristics to Applications

Y Hu, I Willner - Angewandte Chemie International Edition, 2024 - Wiley Online Library
Oligo‐adenine (polyA) is primarily known for its critical role in mRNA stability, translational
status, and gene regulation. Beyond its biological functions, extensive research has …

The improving strategies and applications of nanotechnology-based drugs in hepatocellular carcinoma treatment

X Ren, D Su, D Shi, X Xiang - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the leading causes of tumor-related death
worldwide. Conventional treatments for HCC include drugs, radiation, and surgery. Despite …

Development and applications of lipid hydrophilic headgroups for nucleic acid therapy

W Ma, X Fu, T Zhao, Y Qi, S Zhang, Y Zhao - Biotechnology Advances, 2024 - Elsevier
Nucleic acid therapy is currently the most promising method for treating tumors and genetic
diseases and for preventing infectious diseases. However, the biggest obstacle to this …

Dancing with Nucleobases: Unveiling the Self-Assembly Properties of DNA and RNA Base-Containing Molecules for Gel Formation

PL Scognamiglio, C Vicidomini, GN Roviello - Gels, 2023 - mdpi.com
Nucleobase-containing molecules are compounds essential in biology due to the
fundamental role of nucleic acids and, in particular, G-quadruplex DNA and RNA in life …

One‐Pot Controllable Assembly of a Baicalin‐Condensed Aptamer Nanodrug for Synergistic Anti‐Obesity

J Tian, X He, X Lan, X Liang, Z Zhong, L Zhu, K Chen… - Small, 2023 - Wiley Online Library
The rapid, simple and low‐cost preparation of DNA micro‐nano‐architectures remain
challenging in biosensing and therapy. Polymerase chain reaction (PCR)‐driven DNA micro …