Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

The erasure of epigenetic modifications across the genome of somatic cells is an essential
requirement during their reprogramming into induced pluripotent stem cells (iPSCs). Vitamin …

Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …

Food systems of the future will need to face an increasingly clear reality–that a protein-rich
diet is essential for good health, but traditional meat products will not suffice to ensure safety …

Chromosomal architecture is known to influence gene expression, yet its role in controlling
cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem …

The development of neural interfaces with superior biocompatibility and improved tissue
integration is vital for treating and restoring neurological functions in the nervous system. A …

Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …

The epigenetic mechanisms that maintain differentiated cell states remain incompletely
understood. Here we employed histone mutants to uncover a crucial role for H3K36 …

Cell fate transitions involve rapid gene expression changes and global chromatin
remodeling, yet the underlying regulatory pathways remain incompletely understood. Here …

Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine;
however, their potential clinical application is hampered by the low efficiency of somatic cell …