Vascular calcification (VC) is one of the major causes of cardiovascular morbidity and
mortality in patients with chronic kidney disease (CKD). VC is a complex process expressing …

Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in
the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and …

To increase our understanding of the genetic basis of adiposity and its links to
cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of …

Genome-wide association studies have identified 32 loci influencing body mass index, but
this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta …

The osteoblastic and adipocytic lineages arise from mesenchymal stem cells (MSCs), but
few regulators of self-renewal and early cell-fate decisions are known. Here, we show that …

The bone marrow niche is a dynamic and complex microenvironment that can both regulate,
and be regulated by the bone matrix. Within the bone marrow (BM), mesenchymal stromal …

Importance of the field: Mesenchymal stem cells have the ability to differentiate into
osteoblasts, chondrocytes and adipocytes. Along with differentiation, MSCs can modulate …

In the year 2000, Hanahan and Weinberg defined the six Hallmarks of Cancer as: self-
sufficiency in growth signals, evasion of apoptosis, insensitivity to antigrowth mechanisms …

In most animals, sex determination occurs at conception, when sex chromosomes are
segregated following Mendelian laws. However, in multiple reptiles and fishes, this genetic …

Introduction: Transcriptional coactivator with PDZ-binding motif (TAZ) is known to bind to a
variety of transcription factors to control cell differentiation and organ development. Recently …