The choice of protecting groups is one of the decisive factors in the successful realization of
a complex, demanding synthetic project. The protecting groups used influence the length …

The field of carbohydrate chemistry has occupied the minds and hearts of many scientists for
over a hundred years and, as we enter the twenty‐first century, it continues to be both …

A molecule is usually understood to be a stable collection of atoms connected by a
continuous network of covalent bonds. The development of methods for constructing these …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The advent of organic synthesis and the understanding of the molecule as they occurred in
the nineteenth century and were refined in the twentieth century constitute two of the most …

The recent discovery of several potent antiturnor antibiotics containing (Z)-enediynes or
rented systems has pushed the exploration of enediynes to the forefront of chemical and …

This review article focuses on the molecular aspects of DNA cleavage by synthetic chemical
nucleases (transition metal complexes endowed with redox properties and DNA affinity) and …

The discovery and development of the o-iodoxybenzoic acid (IBX) reaction with certain
unsaturated N-aryl amides (anilides) to form heterocycles are described. The application of …

With a number of antibody–drug conjugates (ADCs) approved for clinical use as targeted
cancer therapies and numerous candidates in clinical trials, the field of ADCs is emerging as …

The systematic modification of natural products through diverted total synthesis is a powerful
concept for the systematic modification of natural products with the aim of studying …