[HTML][HTML] A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation
We propose a novel mathematical and numerical model for cardiac electromechanics,
wherein biophysically detailed core models describe the different physical processes …
wherein biophysically detailed core models describe the different physical processes …
Mathematical modeling of active contraction of the human cardiac myocyte: a review
Background and objective In this present research paper, a mathematical model has been
developed to study myocyte contraction in the human cardiac muscle, using the Land model …
developed to study myocyte contraction in the human cardiac muscle, using the Land model …
[HTML][HTML] 3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …
Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease
H Martinez-Navarro, X Zhou… - Annual Review of …, 2024 - annualreviews.org
A healthy heart shows intrinsic electrical heterogeneities that play a significant role in
cardiac activation and repolarization. However, cardiac diseases may perturb the baseline …
cardiac activation and repolarization. However, cardiac diseases may perturb the baseline …
Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy
Cardiomyopathies have unresolved genotype–phenotype relationships and lack disease-
specific treatments. Here we provide a framework to identify genotype-specific …
specific treatments. Here we provide a framework to identify genotype-specific …
[HTML][HTML] A computationally efficient physiologically comprehensive 3D–0D closed-loop model of the heart and circulation
Computer models of cardiac electro-mechanics (EM) show promise as an effective means
for the quantitative analysis of clinical data and, potentially, for predicting therapeutic …
for the quantitative analysis of clinical data and, potentially, for predicting therapeutic …
Simultaneous widefield voltage and dye-free optical mapping quantifies electromechanical waves in human induced pluripotent stem cell-derived cardiomyocytes
Coupled electromechanical waves define a heart's function in health and diseases. Optical
mapping of electrical waves using fluorescent labels offers mechanistic insights into cardiac …
mapping of electrical waves using fluorescent labels offers mechanistic insights into cardiac …
An implementation of patient-specific biventricular mechanics simulations with a deep learning and computational pipeline
Parameterised patient-specific models of the heart enable quantitative analysis of cardiac
function as well as estimation of regional stress and intrinsic tissue stiffness. However, the …
function as well as estimation of regional stress and intrinsic tissue stiffness. However, the …
[HTML][HTML] An accurate, robust, and efficient finite element framework with applications to anisotropic, nearly and fully incompressible elasticity
Fiber-reinforced soft biological tissues are typically modeled as hyperelastic, anisotropic,
and nearly incompressible materials. To enforce incompressibility a multiplicative split of the …
and nearly incompressible materials. To enforce incompressibility a multiplicative split of the …
In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity, heterogeneity and Purkinje in human
Human-based modelling and simulation offer an ideal testbed for novel medical therapies to
guide experimental and clinical studies. Myocardial infarction (MI) is a common cause of …
guide experimental and clinical studies. Myocardial infarction (MI) is a common cause of …