Antibiotic use is becoming increasingly challenging with the emergence of multidrug-
resistant organisms. Pharmacokinetic (PK) alterations result from complex pathophysiologic …

治疗药物监测是维持万古霉素疗效和预防不良反应的重要手段, 并有助于制定个体化的给药剂量
方案. 随着中国和美国指南关于治疗药物监测指标的更新, 以24 h 药-时曲线下面积(AUC 24 h) …

Methicillin-resistant Staphylococcus aureus (MRSA) is challenging to treat due to a lack of
guidance for clinicians. The daptomycin and ceftaroline combination is promising for treating …

Introduction Bayesian approaches to patient phenotyping in clinical observational studies
have been limited by the computational challenges associated with applying the Markov …

Background Vancomycin regimens are designed to achieve an area under the
concentration-time curve/minimum inhibitory concentration (AUC/MIC) ratio ranging …

Background The revised US consensus guidelines on vancomycin therapeutic drug
monitoring (TDM) recommend obtaining trough and peak samples to estimate the area …

Background: Vancomycin Bayesian modeling provides 24-hour area under the curve
(AUC24) estimations. However, the agreement between two-concentration and one …

Background Current vancomycin monitoring guidelines recommend monitoring 24-hour
area under the concentration-time curve (AUC) to minimum inhibitory concentration ratios for …

Dose‐prediction software is recommended to enable area under the curve over 24 h
(AUC24)‐guided dosing of the antibiotic vancomycin. However, uncertainty remains about …

Background: Two methods of area under the curve (AUC) dosing are recommended in
vancomycin consensus guidelines: first-order calculations utilizing 2 vancomycin …