Sequence database search engines are bioinformatics algorithms that identify peptides from
tandem mass spectra using a reference protein sequence database. Two decades of …

Unbiased data-independent acquisition (DIA) strategies have gained increased popularity in
the field of quantitative proteomics. The integration of ion mobility separation (IMS) into DIA …

Consistent and accurate quantification of proteins by mass spectrometry (MS)-based
proteomics depends on the performance of instruments, acquisition methods and data …

Label-free quantification (LFQ) with a specific and sequentially integrated workflow of
acquisition technique, quantification tool and processing method has emerged as the …

The possibility to record proteomes in high throughput and at high quality has opened new
avenues for biomedical research, drug discovery, systems biology, and clinical translation …

Myelin membranes are dominated by lipids while the complexity of their protein composition
has long been considered to be low. However, numerous additional myelin proteins have …

During the translation surveillance mechanism known as ribosome-associated quality
control, the ASC-1 complex (ASCC) disassembles ribosomes stalled on the mRNA. Here …

The label-free proteome quantification (LFQ) is multistep workflow collectively defined by
quantification tools and subsequent data manipulation methods that has been extensively …

Proteome and transcriptome analyses aim at comprehending the molecular profiles of the
brain, its cell-types and subcellular compartments including myelin. Despite the relevance of …

In the last decade, a revolution in liquid chromatography-mass spectrometry (LC-MS) based
proteomics was unfolded with the introduction of dozens of novel instruments that …