Protein synthesis initiation in eukaryotic cells
WC Merrick, GD Pavitt - Cold Spring Harbor perspectives …, 2018 - cshperspectives.cshlp.org
This review summarizes our current understanding of the major pathway for the initiation
phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe …
phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe …
Roadblocks and resolutions in eukaryotic translation
AP Schuller, R Green - Nature Reviews Molecular Cell Biology, 2018 - nature.com
During protein synthesis, ribosomes encounter many roadblocks, the outcomes of which are
largely determined by substrate availability, amino acid features and reaction kinetics …
largely determined by substrate availability, amino acid features and reaction kinetics …
ALS mutations of FUS suppress protein translation and disrupt the regulation of nonsense-mediated decay
M Kamelgarn, J Chen, L Kuang, H Jin… - Proceedings of the …, 2018 - National Acad Sciences
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease
characterized by preferential motor neuron death. Approximately 15% of ALS cases are …
characterized by preferential motor neuron death. Approximately 15% of ALS cases are …
Translational readthrough potential of natural termination codons in eucaryotes–The impact of RNA sequence
M Dabrowski, Z Bukowy-Bieryllo, E Zietkiewicz - RNA biology, 2015 - Taylor & Francis
Termination of protein synthesis is not 100% efficient. A number of natural mechanisms that
suppress translation termination exist. One of them is STOP codon readthrough, the process …
suppress translation termination exist. One of them is STOP codon readthrough, the process …
[HTML][HTML] Multi-color single-molecule imaging uncovers extensive heterogeneity in mRNA decoding
Summary mRNA translation is a key step in decoding genetic information. Genetic decoding
is surprisingly heterogeneous because multiple distinct polypeptides can be synthesized …
is surprisingly heterogeneous because multiple distinct polypeptides can be synthesized …
Exploiting non-canonical translation to identify new targets for T cell-based cancer immunotherapy
CM Laumont, C Perreault - Cellular and molecular life sciences, 2018 - Springer
Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of
protein-coding genes in non-canonical reading frames and translation of allegedly non …
protein-coding genes in non-canonical reading frames and translation of allegedly non …
Selective translation complex profiling reveals staged initiation and co-translational assembly of initiation factor complexes
S Wagner, A Herrmannová, V Hronová, S Gunišová… - Molecular cell, 2020 - cell.com
Translational control targeting the initiation phase is central to the regulation of gene
expression. Understanding all of its aspects requires substantial technological …
expression. Understanding all of its aspects requires substantial technological …
Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae
In this review, we provide an overview of protein synthesis in the yeast Saccharomyces
cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other …
cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other …
Translation of small downstream ORFs enhances translation of canonical main open reading frames
In addition to canonical open reading frames (ORFs), thousands of translated small ORFs
(containing less than 100 codons) have been identified in untranslated mRNA regions …
(containing less than 100 codons) have been identified in untranslated mRNA regions …