ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals
Abstract Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is
a label-free, non-destructive technique that can be applied to a vast range of biological …
a label-free, non-destructive technique that can be applied to a vast range of biological …
Challenges in the development of soft sensors for bioprocesses: A critical review
Among the greatest challenges in soft sensor development for bioprocesses are variable
process lengths, multiple process phases, and erroneous model inputs due to sensor faults …
process lengths, multiple process phases, and erroneous model inputs due to sensor faults …
A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing
As competition in the biopharmaceutical market gets keener due to the market entry of
biosimilars, process analytical technologies (PATs) play an important role for process …
biosimilars, process analytical technologies (PATs) play an important role for process …
AI-ML applications in bioprocessing: ML as an enabler of real time quality prediction in continuous manufacturing of mAbs
As continuous manufacturing of biotherapeutics gains steam, there is an increasing interest
in using machine learning (ML) techniques for real time prediction of product quality and for …
in using machine learning (ML) techniques for real time prediction of product quality and for …
[HTML][HTML] Digitization in bioprocessing: The role of soft sensors in monitoring and control of downstream processing for production of biotherapeutic products
Owing to the advancement in the technologies, the vision of smart manufacturing is not
implausible. Development of sophisticated measuring tools, modelling approaches …
implausible. Development of sophisticated measuring tools, modelling approaches …
Recent advances in integrated process analytical techniques, modeling, and control strategies to enable continuous biomanufacturing of monoclonal antibodies
V Chopda, A Gyorgypal, O Yang… - Journal of Chemical …, 2022 - Wiley Online Library
Continuous bioprocessing is significantly changing the biological drugs (or biologics)
manufacturing landscape by potentially improving product quality, process stability, and …
manufacturing landscape by potentially improving product quality, process stability, and …
Continuous integrated manufacturing for biopharmaceuticals: A new paradigm or an empty promise?
Continuous integrated bioprocessing has elicited considerable interest from the biopharma
industry for the many purported benefits it promises. Today many major biopharma …
industry for the many purported benefits it promises. Today many major biopharma …
Towards autonomous operation by advanced process control—process analytical technology for continuous biologics antibody manufacturing
H Helgers, A Schmidt, LJ Lohmann, FL Vetter… - Processes, 2021 - mdpi.com
Continuous manufacturing opens up new operation windows with improved product quality
in contrast to documented lot deviations in batch or fed-batch operations. A more …
in contrast to documented lot deviations in batch or fed-batch operations. A more …
Challenges in process control for continuous processing for production of monoclonal antibody products
Continuous processing has been garnering much interest lately for production of
biopharmaceutical products. Purported benefits include higher productivity (10-15X) …
biopharmaceutical products. Purported benefits include higher productivity (10-15X) …
Sensors and chemometrics in downstream processing
A Dürauer, A Jungbauer… - Biotechnology and …, 2024 - Wiley Online Library
The biopharmaceutical industry is still running in batch mode, mostly because it is highly
regulated. In the past, sensors were not readily available and in‐process control was mainly …
regulated. In the past, sensors were not readily available and in‐process control was mainly …