With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Reactive oxygen species (ROS) play a dual role in the initiation, development, suppression,
and treatment of cancer. Excess ROS can induce nuclear DNA, leading to cancer initiation …

Imaging mass spectrometry has become a mature molecular mapping technology that is
used for molecular discovery in many medical and biological systems. While powerful by …

Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to
hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly …

Simple Summary Colorectal cancer (CRC) is the third-most diagnosed cancer and the
second-leading cause of cancer-related deaths worldwide. Limitations in early and accurate …

Reprogramming of lipid metabolism has received increasing recognition as a hallmark of
cancer cells because lipid dysregulation and the alteration of related enzyme profiles are …

Exposure of tumor cells to ionizing radiation (IR) alters the microenvironment, particularly the
fatty acid (FA) profile and activity. Moreover, abnormal FA metabolism, either catabolism or …

Gangliosides in the outer leaflet of the plasma membrane of eukaryotic cells are essential for
many cellular functions and pathogenic interactions. How gangliosides are dynamically …

Objective Lipidomic changes were causally linked to metabolic diseases, but the scenario
for colorectal cancer (CRC) is less clear. We investigated the CRC lipidome for putative …