Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review

FF Tuon, LR Dantas, PH Suss, VS Tasca Ribeiro - Pathogens, 2022 - mdpi.com
Pseudomonas aeruginosa is associated with several human infections, mainly related to
healthcare services. In the hospital, it is associated with resistance to several antibiotics …

Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

[HTML][HTML] Biofilms by bacterial human pathogens: Clinical relevance-development, composition and regulation-therapeutical strategies

A Schulze, F Mitterer, JP Pombo, S Schild - Microbial Cell, 2021 - ncbi.nlm.nih.gov
Notably, bacterial biofilm formation is increasingly recognized as a passive virulence factor
facilitating many infectious disease processes. In this review we will focus on bacterial …

Revisiting the virulence hallmarks of Pseudomonas aeruginosa: a chronicle through the perspective of quorum sensing

J Chadha, K Harjai, S Chhibber - Environmental microbiology, 2022 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of mortality
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …

Updates on the pathogenicity status of Pseudomonas aeruginosa

MW Azam, AU Khan - Drug discovery today, 2019 - Elsevier
Highlights•MDR P. aeruginosa is one of the major causes of the nosocomial
infections.•Virulence factors involved in pathogenicity were described.•Potential inhibitors of …

Quorum-sensing systems as targets for antivirulence therapy

T Defoirdt - Trends in microbiology, 2018 - cell.com
The development of novel therapies to control diseases caused by antibiotic-resistant
pathogens is one of the major challenges we are currently facing. Many important plant …

The hierarchy quorum sensing network in Pseudomonas aeruginosa

J Lee, L Zhang - Protein & cell, 2015 - academic.oup.com
Pseudomonas aeruginosa causes severe and persistent infections in immune compromised
individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa …

Bacterial quorum sensing: its role in virulence and possibilities for its control

ST Rutherford, BL Bassler - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Quorum sensing is a process of cell–cell communication that allows bacteria to share
information about cell density and adjust gene expression accordingly. This process …

The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore

J Lin, J Cheng, Y Wang, X Shen - Frontiers in cellular and infection …, 2018 - frontiersin.org
The Pseudomonas quinolone signal (PQS) has been studied primarily in the context of its
role as a quorum-sensing signaling molecule. Recent data suggest, however, that this …

Targeting virulence: can we make evolution-proof drugs?

RC Allen, R Popat, SP Diggle, SP Brown - Nature Reviews Microbiology, 2014 - nature.com
Antivirulence drugs are a new type of therapeutic drug that target virulence factors,
potentially revitalising the drug-development pipeline with new targets. As antivirulence …