Pyrazinamide (PZA) is the only drug for the elimination of latent Mycobacterium tuberculosis
(MTB) isolates. However, due to the increased number of PZA-resistance, the chances of the …

Network biology, an interdisciplinary field at the intersection of computational and biological
sciences, is critical for deepening understanding of cellular functioning and disease. While …

The protein-protein interaction (PPI) network of an organism serves as a skeleton for its
signaling circuitry, which mediates cellular response to environmental and genetic cues …

The process of parturition involves the transformation of the quiescent myometrium (uterine
smooth muscle) to the highly contractile laboring state. This is thought to be driven by …

Motivation As cancer genomics initiatives move toward comprehensive identification of
genetic alterations in cancer, attention is now turning to understanding how interactions …

Abstract Background StrongestPath is a Cytoscape 3 application that enables the analysis of
interactions between two proteins or groups of proteins in a collection of protein–protein …

Background Signaling pathways are the key biological mechanisms that transduce
extracellular signals to affect transcription factor mediated gene regulation within cells. A …

The expanding generation of dynamic biological data requires approaches that integrate
and analyze information from different types of cellular processes–metabolism, regulation …

Motivation A series of recently introduced algorithms and models advocates for the
existence of a hyperbolic geometry underlying the network representation of complex …

PathLinker is a graph-theoretic algorithm for reconstructing the interactions in a signaling
pathway of interest. It efficiently computes multiple short paths within a background protein …