Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

At least five muscarinic receptors genes have been cloned and expressed. Muscarinic
receptors act via activation of G proteins: m1, m3 and m5 muscarinic receptors couple to …

Endothelial cells release several compounds, including prostacyclin, NO, and endothelium-
derived hyperpolarizing factor (EDHF), that mediate the vascular effects of vasoactive …

In arteries, muscarinic agonists such as acetylcholine release an unidentified, endothelium-
derived hyperpolarizing factor (EDHF) which is neither prostacyclin nor nitric oxide,,. Here …

Nitric oxide (NO)-induced relaxation is associated with increased levels of cGMP in vascular
smooth muscle cells. However, the mechanism by which cGMP causes relaxation is …

Endothelium‐dependent hyperpolarizing factor (EDHF) is a powerful vasodilator influence in
small resistance arteries and thus an important modulator of blood pressure and flow. As the …

Endothelial cells synthesize and release vasoactive mediators in response to various
neurohumoural substances (eg bradykinin or acetylcholine) and physical stimuli (eg cyclic …

The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium
channels are reviewed. Potassium channels regulate the membrane potential of smooth …

The endothelium controls vascular tone not only by releasing nitric oxide (NO) and
prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth …

ATP-sensitive potassium (KATP) channels are present in the surface and internal
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …