Glucocorticoids are steroid hormones that regulate multiple aspects of glucose homeostasis.
Glucocorticoids promote gluconeogenesis in liver, whereas in skeletal muscle and white …

Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …

Stress is a condition of human existence and a factor in the expression of disease. A broader
view of stress is that it is not just the dramatic stressful events that exact their toll but rather …

Since the discovery of the beneficial effects of adrenocortical extracts for treating adrenal
insufficiency more than 80 years ago, glucocorticoids (GC) and their cognate, intracellular …

Glucocorticoids (GCs) are steroidal ligands for the GC receptor (GR), which can function as
a ligand-activated transcription factor. These steroidal ligands and derivatives thereof are …

The allostatic load model proposed by McEwen and Stellar refers to the wear and tear that
the body experiences due to the repeated use of adaptive responses to stress, as well as the …

It has become increasingly clear that glucocorticoid signalling not only comprises the
binding of the glucocorticoid receptor (GR) to its response element (GRE), but also involves …

There is a broad consensus that glucocorticoids (GCs) exert anti-inflammatory effects largely
by inhibiting the function of nuclear factor κB (NFκB) and consequently the transcription of …

Glucocorticoids play important roles in the regulation of distinct aspects of adipocyte biology.
Excess glucocorticoids in adipocytes are associated with metabolic disorders, including …

RANKL is a tumor necrosis factor (TNF)-like factor secreted by mesenchymal cells,
osteoblast derivatives, and T cells that is essential for osteoclastogenesis. In osteoblasts …