Circulating cell-free nucleic acids as epigenetic biomarkers in precision medicine

B Rahat, T Ali, D Sapehia, A Mahajan, J Kaur - Frontiers in genetics, 2020 - frontiersin.org
The circulating cell-free nucleic acids (ccfNAs) are a mixture of single-or double-stranded
nucleic acids, released into the blood plasma/serum by different tissues via apoptosis …

Concentration of cell-free DNA in different tumor types

OE Bryzgunova, MY Konoshenko… - Expert Review of …, 2021 - Taylor & Francis
ABSTRACT Introduction: Cell-free DNA (cfDNA) circulates in the blood for a long time. The
levels of cfDNA in the blood are assayed in cancer diagnostics because they are closely …

Evaluating the quantity, quality and size distribution of cell-free DNA by multiplex droplet digital PCR

M Alcaide, M Cheung, J Hillman, SR Rassekh… - Scientific reports, 2020 - nature.com
Cell-free DNA (cfDNA) has become a comprehensive biomarker in the fields of non-invasive
cancer detection and monitoring, organ transplantation, prenatal genetic testing and …

Identification and characterization of extrachromosomal circular DNA in maternal plasma

STK Sin, P Jiang, J Deng, L Ji… - Proceedings of the …, 2020 - National Acad Sciences
We explored the presence of extrachromosomal circular DNA (eccDNA) in the plasma of
pregnant women. Through sequencing following either restriction enzyme or Tn5 …

Clinical utility of liquid biopsy in breast cancer: A systematic review

G Duque, C Manterola, T Otzen, C Arias… - Clinical …, 2022 - Wiley Online Library
Advancements in genetic sequencing techniques along with the identification of specific
mutations and structural changes in multiple cancer genes, make it possible to identify …

Cell free DNA as an evolving liquid biopsy biomarker for initial diagnosis and therapeutic nursing in Cancer-An evolving aspect in Medical Biotechnology

SK Ray, S Mukherjee - Current Pharmaceutical Biotechnology, 2022 - ingentaconnect.com
Cell-free DNA (cfDNA) is present in numerous body fluids and generally blood cells. It is
undoubtedly the utmost promising tool among all components of liquid biopsy. Liquid biopsy …

Evaluation of automated techniques for extraction of circulating cell-free DNA for implementation in standardized high-throughput workflows

S Lehle, J Emons, CC Hack, F Heindl, A Hein… - Scientific Reports, 2023 - nature.com
Abstract Analysis of circulating cell-free DNA (ccfDNA) is a suitable tool for detecting somatic
mutations for the purpose of making decisions on treatment, monitoring treatment response …

Circulating cell-free DNA in breast cancer: Searching for hidden information towards precision medicine

M Panagopoulou, M Esteller, E Chatzaki - Cancers, 2021 - mdpi.com
Simple Summary Our research focuses in the elucidation of the nature of circulating cell-free
DNA (ccfDNA) as a biological entity and its exploitation as a liquid biopsy biomaterial …

The utility of repetitive cell-free DNA in cancer liquid biopsies

U Gezer, AJ Bronkhorst, S Holdenrieder - Diagnostics, 2022 - mdpi.com
Liquid biopsy is a broad term that refers to the testing of body fluids for biomarkers that
correlate with a pathological condition. While a variety of body-fluid components (eg …

The future of lymphoma diagnosis, prognosis, and treatment monitoring in countries with limited access to pathology services

C Chamba, W Mawalla - Seminars in Hematology, 2023 - Elsevier
The world is moving towards precision medicine for cancer. This movement goes hand in
hand with the development of newer advanced technologies for early, precise diagnosis of …