During the last decades, the pleiotropic antitumor functions exerted by type I interferons
(IFNs) have become universally acknowledged, especially their role in mediating …

Simple Summary The treatment of cancer has progressed greatly with the advent of
immunotherapy and gene therapy, including the use of nonreplicating adenoviral vectors to …

Carcinogenesis of human papillomavirus (HPV)-related (+) oropharyngeal squamous cell
carcinoma (OPSCC) differs from HPV-negative (–) OPSCC. HPV-related immune-escape …

Neutrophils display rapid and potent innate immune responses in various diseases. Tumor-
associated neutrophils (TANs) however either induce or overcome immunosuppressive …

In a tumour microenvironment, tumour-associated neutrophils could display two opposing
differential phenotypes: anti-tumour (N1) and pro-tumour (N2) effector cells. Converting N2 …

Malignant melanoma is a type of cancer with high death rates due, in part, to the lack of
efficient treatments once metastases have formed. 1 The tumor suppressor protein p53 is …

In various diseases, the STAT family display various cellular controls over various
challenges faced by the immune system and cell death programs. In this study, we …

Abstract CXCL3 (CXC Motif Chemokine 3), a member of the CXC chemokine subfamily,
operates as a potent chemoattractant for neutrophils, thereby orchestrating the recruitment …

Balancing safety and efficacy is a major consideration for cancer treatments, especially
when combining cancer immunotherapy with other treatment modalities such as …

Immune evasion is an important cancer hallmark and the understanding of its mechanisms
has generated successful therapeutic approaches. Induction of immunogenic cell death …